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Market Overview:

Oligonucleotide Therapy Market size was valued at USD 4,207.20 million in 2021 and is estimated to reach at a compound annual growth rate CAGR of 15.80% over the forecast period 2022 to 2029.

Oligonucleotides talk over with brief chain DNA or RNA which might be usually made by way of the usage of automatic synthesizers. In addition, purification of oligonucleotide is carried out by means of anion exchange chromatography and it’s far followed by the techniques of freezing and desalting. In addition, the synthesis of siRNA duplex oligonucleotide is completed thru an annealing step wherein two purified strands of the oligonucleotide are brought closer collectively in an equimolar ratio. 

There exists a lot of difference between oligonucleotide therapeutics and traditional medication. The oligonucleotide therapeutics are able to retain lower back the expression of particular genes. This component affects the improvement of brand-new oligonucleotides targeting positive genes and treating continual illnesses. Chemically modified synthetic nucleic acids are applied as a way to expand these new oligonucleotide therapeutics. The evolved synthetic oligonucleotides include higher more desirable affinity and in-vivo balance to target mRNA.

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Market Dynamics

The developing prevalence of most cancers is anticipated to power the growth of the market

According to the American Cancer Society, in 2020, the number of recent most cancers cases and deaths is expected at 1.8M new most cancers instances recognized and 606,520 cancer deaths inside the United States. The upward thrust in cancer cases ends in the demand for novel diagnostics, which is one of the principal factors driving the marketplace growth. Moreover, numerous elements, such as increased pollution and the adoption of a sedentary lifestyle, purpose most cancers, CVD, diabetes, and autoimmune diseases. The cancer price has improved drastically in the last few years, and the want for novel therapeutics has multiplied simultaneously. Oligonucleotide therapeutics are gaining traction as they could produce a new elegance of nucleic acid probes known as aptamers, which can be higher probes than monoclonal antibodies. Thus, from the above statements, the growing incidence of cancer is expected to force the marketplace’s growth.

The low range of drug approvals by using the FDA is anticipated to abate the boom of the market.

Due to the stern standards for manufacturing and excessive drug efficacy standards set by way of the regulatory bodies for approval of this remedy and for that reason growing the time required for approval restricts the market’s growth. For example, in January 2020, the marketplace most effective had eleven capsules authorized.

Market Segmentation:

By Type

• Antisense Oligonucleotide
• Aptamer
• Other

By Application

• Infectious Diseases
• Oncology
• Neurodegenerative Disorders
• Cardiovascular Diseases

By End User

• Hospitals
• Research Institutes

Competitive Landscape

The oligonucleotide therapy market is moderately competitive with presence of local as well as global companies. Some of the key players which are contributing to the growth of the market include Kastle Therapeutics, Sarepta Therapeutics, Pfizer Inc., InteRNA Technologies B.V., Santaris, Akcea Therapeutics, Miragen Therapeuutics Inc., Alnylam Pharmaceuticals Inc.,, Biogen Inc., Ionis Pharmaceuticals Inc. The major players are adopting several growth strategies such as product launches, acquisitions, and collaborations, which are contributing to the growth of the oligonucleotide therapy market globally.

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